-- Eric D. Williams. Williams' pick: Chargers 24, Steelers 13 -- Brady Henderson, NFL PrimeTime continues this postseason with extended highlights and analysis following the conclusion of each day's playoff games. Young, meanwhile, flashed his form early before missing some time with a groin injury. -- Sarah Barshop. Aaron Rodgers & Co. have carried the team to a 4-0 start, but after a bye week to figure out what has gone wrong, Mike Pettine's defense will find a way to come up big. His former defensive coordinator, Texans interim head coach Romeo Crennel, called the former No. Yet the only 49ers player with multiple rushing touchdowns this season is Jeff Wilson Jr. (four), who averages 2.9 yards per rush. Matchup rating: 37.4 | Spread: ARI -1.5 (55), What to watch for: Cardinals quarterback Kyler Murray is 6-0 all time at AT&T Stadium. • Transactions » | Injuries » NFL execs, coaches weigh in on QB's future, Why Favre thinks this is the best Rodgers has ever played (1:54), Guide to every Week 6 NFL game: Picks, matchup nuggets, more, Guide to Buccaneers-Packers, Bills-Chiefs: Picks, bold predictions and more, Sources: Lions actively seek to trade Stafford, Source: Chiefs RB Edwards-Helaire likely to play, Sources: Ex-Chargers coach Lynn to be Lions OC, Fins QB coach hire Frye has familiarity with Tua, Williams eyes NFL first: 2 teams in 1 postseason, Texans interview QB McCown, Caldwell for HC job, Finally, Aaron Rodgers vs. Tom Brady: Inside playoff matchup 13 years in making, Why Chiefs' Patrick Mahomes is the premier practitioner of the free play, Matthew Stafford gave Detroit all he had -- on the field and off of it, How Ryan Jensen became the best - and meanest - center in the game, After 13-year playoff drought, Bucs carry hopes of their last NFC championship team, Getting No. The Rams, after last week's close loss to Seattle, have dropped to 17th. Stat to know: Minshew needs 235 passing yards to have the most ever by a Jaguars QB through six games. -- Jenna Laine, • McShay's most recent mock draft » FPI prediction: BAL, 81.0% (by an average of 12.0 points), Matchup must-reads: How to fix Bengals' struggling offense? Baby's pick: Colts 23, Bengals 14 ET | Fox WSH-MIA | SF-LAR | ATL-ARI • Full schedule » | Standings » See Week 6 rankings. What to know for fantasy: After throwing four touchdown passes on 36 attempts in Week 2 against the Cowboys, Ryan has just one touchdown toss over the past three weeks (114 attempts). 1-ranked defense, have struggled with this season has been getting to the quarterback; they're tied for 15th in the league in sacks (11). Matchup rating: 42.2 | Spread: CAR -1.5 (44.5), What to watch for: This game is all about pressure. More NFL coverage », Bold prediction: Mahomes and Deshaun Watson will combine for 750 passing yards. The Week 6 NFL slate is stacked with great matchups. ET | Fox Matchup rating: 40.9 | Spread: BAL -12 (47.5), What to watch for: Baltimore averages 36 runs per game, a monumental challenge for Cincinnati, which has given up the second-most rushing yards this season (167.6 per game). Corey Perrine/Getty Images. Tennessee coach Mike Vrabel was very aggressive last time out, sending defensive backs on the blitz. Denver's defense is 22nd against the run (126.4 yards per game), a prime spot for the Titans and Henry to get back to their smashmouth style of offense. Philadelphia scheming to stop Dalvin Cook and the run while Minnesota's pass rush aims to force Carson Wentz into a tough spot is a matchup of two stalwarts. So it will be interesting to see whether the Chiefs can bounce back despite potentially being without two injured starting offensive linemen and wide receiver Sammy Watkins. Enter Baltimore's Mark Andrews, who is tied for third in the NFL with five receiving scores. What to know for fantasy: Conner has yet to deliver more than 55 rushing yards in a game this season, but he is facing a Chargers team that gave up 174 yards on 25 carries to Indianapolis' Marlon Mack and 114 on Phillip Lindsay's 15 totes for Denver earlier this season. The Big Lead picks in Week 5 had some good and some bad results. Bears 10, Eagles 6. See Week 6 rankings. He is also 13-5-2 ATS when facing teams that enter with losing records. Stat to know: The Cowboys' defense allows a third-down conversion just 26% of the time, second-best in the league -- and the Jets' offense converts only 21% of its third downs, the worst in NFL this season. DET-GB, Thursday: NE 35, NYG 14 Read more. ET | Fox -- Mike Triplett. McClure's pick: Falcons 28, Cardinals 21 The Week 6 NFL schedule is stacked with great matchups. 1 pick, Dolphins move into top five, D is the new MVP: Ravens' D upstaging Jackson, From QB play to his contract, a look at what's ailing Eagles' Ertz, Eagles cleared to host limited fans at home games, "Biggest" Eagles fan sends well-wishes after Prescott's injury, Hurting Browns QB Mayfield still plans to face Steelers, Browns vs. Steelers: Behind the turnarounds, return of Garrett and what win means, Browns' Garrett playing at elite level going into Steelers rematch, Steelers coach Mike Tomlin focused on facing Browns, not Garrett, Steelers' Roethlisberger "proud" of Smith-Schuster's selflessness, Titans have been dominating in the red zone behind Tannehill, Unhappy LB Correa traded by Titans to Jaguars, Texans hire search firm to assist GM search, Falcons shut down facility after positive coronavirus test, Vikings' Mattison ready to step in for injured Cook, Teacher, coach, No. Stat to know: Atlanta wide receiver Calvin Ridley has an NFL-high four 100-yard receiving games this season. Matchup rating: 81.8 | Spread: LAR -3.5 (51.5), What to watch for: The 49ers' struggling offensive line gets its toughest test yet with Aaron Donald & Co. coming to town. 2 For Darnold's sake, Jets must rebuild O-line the Dallas way, Mistakes overshadow career days for Cooper, Prescott, Darnold's return intensifies spotlight on Gase, New QB Hodges brings athleticism, 'fearless' approach, Goal-line turnovers an issue for Chargers, Rivers, How Packers' Matt LaFleur is doing what other first-year coaches haven't: win, Against Packers, Lions can lean on Patricia's success against top offenses, Packers' good vibrations: Rodgers likes 'the vibe on this team', Rewriting the Rodgers narrative, according to his backup center, Panthers (3-2) vs. ESPN Fantasy's Kyle Soppe and ESPN Chalk's Dave Bearman hand out helpful nuggets as well. The Dolphins and Redskins are the only two teams in the NFL that rank in the bottom five in both offensive and defensive efficiency. B/R Expert Consensus NFL Picks for Week 6. Read more. "Obviously he can make any throw, he can hit all the quadrants of the field, and he's leading the league in rushing as quarterbacks. -- Tim McManus, Bold prediction: Ravens quarterback Lamar Jackson will throw at least four TD passes. Matchup rating: 74.6 | Spread: MIN -3 (44), What to watch for: The Eagles are coming off a 10-sack performance, while the Vikings harassed Giants quarterback Daniel Jones last weekend with aggressive blitzes. -- Ben Baby. See Week 6 rankings. See Week 6 rankings. Stat to know: The Giants are last in the NFL in rushing, with just 79.0 yards per game. The Broncos have been one of the league's worst in takeaways this season -- one interception and one fumble recovery in four games -- but the Patriots are tied for eighth in giveaways with seven. Trotter's pick: Steelers 28, Browns 24 Jump to a matchup: Even without Prescott, Cowboys say plan stays the same on offense ... Hopkins credits Murray, Cardinals' playcalling for hot start ... Could Dak still get $100 million? See Week 6 rankings. Yet through five weeks, he has the same number of fantasy points (105.5) as Brandin Cooks and Stefon Diggs combined. ET | Fox • Mahomes chief practitioner of free play Betting nugget: Dak Prescott is 7-2-1 ATS in his career when favored by six or more points (10-0 outright). 43 overall) out of Notre Dame, Kmet has just one reception for 12 yards though five games. Betting nugget: Watson is 8-1 ATS in his career as a road underdog, with four outright wins. This marks the sixth game in the Super Bowl era between teams with a combined record of 0-9 or worse, and the first since 2004. FPI prediction: GB, 65.8% (by an average of 5.6 points), Matchup must-reads: How Packers' Matt LaFleur is doing what other first-year coaches haven't: win ... Against Packers, Lions can lean on Patricia's success against top offenses ... Packers' good vibrations: Rodgers likes 'the vibe on this team' ... Rewriting the Rodgers narrative, according to his backup center, 9:30 a.m. In their Week 6 matchup, the Chiefs won via the ground game. See Week 6 rankings. NFL Week 6 Picks for Every Game By Athlon Sports , 10/14/18, 2:00 PM EDT Athlon's experts predict winners for every game, including the Sunday night showdown between the Chiefs and Patriots Dickerson's pick: Panthers 17, Bears 16 Cleveland (plus 17) at Jacksonville: The Jaguars have only one more game left with a winning team. Stat to know: New Orleans running back Alvin Kamara has been held under 70 rushing yards for four consecutive games. -- Cameron Wolfe, Bold prediction: The Jets won't convert more than five third downs. -- Rob Demovsky. ET | Fox • Depth charts for every team » Miami is the NFL's worst run defense at 176 yards per game. FPI prediction: TB, 53.0% (by an average of 1.1 points), Matchup must-reads: One night in Atlanta 10 years ago, Rodgers became a star ... Brady pokes fun at himself while congratulating LeBron ... Brady's fourth-down gaffe joins list of other interesting errors with time and turnovers, 8:20 p.m. -- Adam Teicher. This is the percentage of the general public betting on each side of a matchup or total. Stat to know: With Ryan Tannehill starting at quarterback, the Titans are 11-3 (.714) and have averaged 30.4 points per game. The Saints' front seven is playing great, and will make Fournette work for it. They'll have to be disciplined and keep Watson from extending plays and finding his speedy receivers down the field. 1-ranked offense and a two-game losing streak versus the No. Betting nugget: Indianapolis is 6-3 ATS as a home favorite since the start of last season, tied for the second-best cover percentage over that span. Betting nugget: Detroit has won and covered all four meetings between these two teams in the past two seasons, including three times as an underdog. NFL experts debate their title window, future at QB, 2021 NFL draft order: Top 28 picks set, with Jags, Jets, Dolphins at the top, What separates Watson and Mahomes? See Week 6 rankings. • Pack want to help Rodgers get ring No. Betting nugget: Quarterbacks making their first career starts are 7-0 ATS this season. See Week 6 rankings. The Packers, meanwhile, have the eighth-best pass block win rate in the NFL (60%). See Week 6 rankings. ET | Fox He's a dynamic player and he's definitely the centerpiece of that offense." Cincinnati Bengals at Indianapolis Colts (-8) Sunday, 1 p.m. ET,FOX. Demovsky's pick: Packers 27, Buccaneers 24 Bears need major upgrades in key positions, Extensions, OBJ and defense: Burning questions facing the Browns' offseason, Deshaun Watson's no-trade clause puts Houston Texans in no-win situation, Buffalo Bills can justify trading Patrick Mahomes pick by reaching Super Bowl, What the Nick Sirianni hire means for Carson Wentz, Philadelphia Eagles, No more quick fixes: Colts must secure long-term successor to Philip Rivers, The biggest looming free-agent decisions for all 32 NFL teams: Who has a salary-cap crunch, What now for Drew Brees and the Saints? What to know for fantasy: In Week 5, Will Fuller doubled his catch total for the season and jumped up 58 spots in the wide receiver fantasy ranks. That's the best win percentage (minimum 10 starts) and most team points per game for a Titans/Oilers QB since the 1970 merger. 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